Cannabis Labelling on Industrial Hemp Chemistry Literature Review – Description
Literature Review – The writing is very choppy and does not make strong points, rather is summarizes literature, rather than identifying gaps and clearly explaining how your work will fill those gaps. Many paragraphs begin with words that are typically used for extending a thought, such a “moreover” or “however.” Such as page 5, “However, none of these studies have passed the scrutiny of clinical trials [ 49, 50]. ” A new paragraph should not start like this, but rather, should have topic/introduction sentences that the following sentences will expound upon, and the last sentence should summarizes/conclude the topic, and if it is the last sentence of a subsection, should contain a mini-problem statement that justifies the work being proposed. The literature review reads more like a summary rather than a review, that is, analysis of the literature. Some places are difficult to follow because the information is not well organized. Some paragraphs cover multiple topics and sentences do not flow with each other. For example, the paragraph below from pages 6-7 should be focused on GBM as a tumor that causes necrosis and hypoxia — based on the introduction sentence. However, the complement (words placed in the stress position, i.e., end of the sentence) — necrosis and hypoxia — are not the focus at all. Necrosis is mentioned near the end of the paragraph and hypoxia is never mentioned again. The paragraph mentions age, EGFR, lack of understanding about GBM, biomarkers…this is confusing to the reader. The document is like this throughout. This is frustrating to read, and this document needs a lot of work before it can be released to the committee. 2.1.1. Glioblastoma pathogenesis, pharmacotherapy, and treatments GBM is classified by the World Health Organization (WHO) as a high-grade IV tumor that causes necrosis and hypoxia. Over the last decade, the number of patients with gliomas has significantly increased. It is evident that conventional therapies such as chemotherapy and surgery help in GBM treatment by increase the life expectancy among 50% of glioma patients [6- 8]. EGFR has long been considered a potential drug target for the treatment of GBM. Several studies have confirmed that drug-inhibited EGFR in GBM cell lines has shown therapeutic effects [57, 58]. Since GBM is as a high-grade IV tumor, the pathogenesis of GBM is not well understood despite the fact that there are approaches aimed at boosting effectiveness in treatment [ 55, 56]. High microvascular proliferation with local necrosis appears to be the best method to histologically determine GBM [57- 64]. Also, a few biomarkers, such as IDH1, 2 and P53 mutations, have been used as diagnostic tools for determining disease progression. Most patients with GBM are of advanced age, which has led to many issues in diagnosing the disease in its early stages [54].Figure 1 on page 6 is not mentioned until page 8; however, it does not seem to make sense with what is being discussed. The writing is distracting and requires re-reading sentences more than once to understand the ideas. This is frustrating to the reader. Make sure you place the figures close to where they are discussed. Initially is seems as if Figure 2 (on page 11) was not discussed in the text, but it is not mentioned until page 14. This is too far away. The thesis/dissertation guidelines specify that the figures need to be close to where they are discussed. Figures should be on the same page where they are referenced, or the page immediately before or after the figure. Be sure to provide references for the figures you are using if you did not make them yourself.The most glaring deficiency in the written document is the lack of a clear problem statement/research question, goal, hypothesis and research objectives/specific aims. The most likely reason for this is that the literature and not been analyzed, rather, it has been summarized. No gaps in knowledge have been identified that provide solid justification for the work. What is the hypothesis?
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