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PU Cystic Fibrosis Case Study

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PU Cystic Fibrosis Case Study – Question Description

I’m working on a genetics case study and need the explanation and answer to help me learn.

Cathy is pregnant for the second time. Her first child Donald, has Cystic fibrosis (CF).  Cathy has two brothers Charles and Colin and a sister Cindy. Charles is married to an unrelated woman, Carolyn, and has a 2-year- old daughter, Debbie. Cathy’s parents are Bob and Betty. Betty’s sister Barbara is the mother of Cathy’s husband, Calvin. There is no previous family history of Cystic fibrosis.
What is the pattern of transmission of Cystic Fibrosis?
What is the risk for Cystic Fibrosis for Cathy’s next child?
Which people in this pedigree are obligate heterozygotes?

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