Anxiolytic medications significantly encourage sedation and lessen anxiety and its allied symptoms. Generalized anxiety disorder is characterized by restlessness, feeling on edge, easily exhausted, inability to concentrate, irritability, muscle tension and sleep disturbance—anxiolytic acts on specific receptors to avert the above clinical features demonstrated by persons with generalized anxiety disorder. Benzodiazepines are a major vital treatment for anxiety-related disorders (Gomez, et al., 2019). Benzodiazepines exist and are prescribed in different formulations for all age groups. Benzodiazepines are metabolized by the phase I oxidative CYP enzyme system and phase II glucuronidation. The active metabolite desmethyldiazepam metabolizes long-acting benzodiazepines. The FDA recommends Buspirone and alzopram anxiolytics. All benzodiazepines, sedatives hypnotic and non-benzodiazepines produce a common pharmacodynamics effect. Pharmacodynamics of anxiolytics include drowsiness and psychomotor deficiency. Benzodiazepines yield antiepileptic actions,

amnesia and muscle lessening. Non- benzodiazepines only entail a focus on sedation and psychomotor impairment. Various factors such as gender and age impact the pharmacokinetic and pharmacodynamics of anxiolytic medication. The elderly patients experience ease in sedation and psychomotor impairment compared to the young adult populations (DeMartini, et al., 2019). First-Line Treatment For Generalized Anxiety Disorder Essay Another factor is gender. Zolpidem anxiolytic plasma concentrations are significantly higher than in men. The FDA thus instituted recommendations to reduce doses prescribed to enhance efficacy. The metabolism and elimination are much easier among the young population than in the elderly due to kidney compromise. Genetic variations among individuals impair how anxiolytic medications are metabolized in the body. Sex differences in body enzymes, body mass, muscle mass, and blood volume significantly contribute to pharmacokinetics variability among persons. Generalized anxiety disorder treatment options utilize pharmacologic and non-pharmacologic therapy to lessen anxiety. Both therapies tend to reduce the anxiety state and prevent bizarre behaviors. Antidepressants are used to suppress overt mood; anxiolytics reduce anxiety stressors (Li et al., 2019). Psychotherapy techniques include talk therapy, cognitive behavioral therapy and acceptance and commitment therapy. First-Line Treatment For Generalized Anxiety Disorder Essay